Endocrine Abstracts

In most obese patients, obesity is associated with a low-grade inflammation of white adipose tissue resulting from chronic activation of the innate immune system and which can subsequently lead to insulin resistance, impaired glucose tolerance and even diabetes. It is still not clear role of acquired immune response in obesity and related comorbidites such as asthma, cancer or autoimmune diseases. The aim of our study was to compare level s of IL-17 and IL23 in sever obese wom...

It was postulated that different therapeutic approaches could influence the markers of inflammation in obesity but it is unknown whether overweight women with and without metabolic syndrome have the same degrees of inflammatory state. The aim of our study was to compare level of hs-CRP in obese women without other components of metabolic syndrome with hs-CRP in women with metabolic syndrome (according IDF criteria). Overweight body mass index-matched women without (OW)) (n<...

Visfatin is a newly discovered adipokine found in abundance in visceral fat. Leptin is well known marker of fat mass in the body but also one aspect of leptin is its action as a proinflammatory cytokine. Recent studies, both in vitro and in vivo, indicated that visfatin is also one of the inflammatory cytokines, although the relationship between visfatin and insulin resistance remains still unclear. The aim of our study was to assess the association between visfa...

Visfatin is expressed in visceral adipose tissue and is up regulated in some animal models of obesity. Insulin-mimetic actions of visfatin may be part of the feedback regulation of glucose homeostasis, so plasma glucose or insulin may have effect on visfatin levels in humans. The aim of study was to investigate plasma glucose, insulin and visfatin during oral glucose tolerance test (OGTT, 75 gr) in obese women. 22 obese women (age: 36.73±1.88 yrs; BMI 34.72±0.67 kg/m...

Visfatin, a new adipokine, facilitates adipogenesis and has insulin-mimetic properties. There are data that hyperglycemia causes an increase in plasma visfatin levels in people with T2DM this increase gets more prominent as the glucose intolerance worsens. The aim of the study was to investigate plasma visafatin, leptin and adiponectin in obese women with normal and impaired glucose tolerance. Thirteen obese women (age: 34.50±2.57 yrs; BMI 35.05±0.57 kg/m2) with norm...